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Literature summary extracted from

  • Akita, K.; Fujimura, Y.; Bajotto, G.; Shimomura, Y.
    Inhibition of branched-chain alpha-ketoacid dehydrogenase kinase by thiamine pyrophosphate at different potassium ionic levels (2009), Biosci. Biotechnol. Biochem., 73, 1189-1191.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.4 alpha-Chloroisocaproate
-
 Rattus norvegicus
2.7.11.4 thiamine diphosphate
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.4 K+
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.4 heart
-
 Rattus norvegicus
-
2.7.11.4 liver
-
 Rattus norvegicus
-

Synonyms

EC Number Synonyms Comment Organism
2.7.11.4 branched-chain alpha-ketoacid dehydrogenase kinase
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.11.4 0.0032
-
 thiamine diphosphate 20 mM K+ Rattus norvegicus
2.7.11.4 0.0164
-
 thiamine diphosphate 100 mM K+ Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.4 0.0046
-
 20 mM K+ Rattus norvegicus thiamine diphosphate
2.7.11.4 0.006
-
 100 mM K+ Rattus norvegicus alpha-Chloroisocaproate
2.7.11.4 0.008
-
 100 mM K+ Rattus norvegicus thiamine diphosphate
2.7.11.4 0.031
-
 10 mM K+ Rattus norvegicus alpha-Chloroisocaproate